The clinical efficacy of Shenxiang Suhe Pill administration in posterior circulation ischemic vertigo: A randomized controlled trial.

BACKGROUND: Shenxiang Suhe Pill (SXSHP) is a traditional Chinese medicine (TCM) widely used to treat coronary heart disease. The present study aims to investigate the effect of SXSHP on posterior circulation ischemic (PCI) vertigo. METHODS: One hundred and twenty patients with PCI vertigo were randomly divided into the control, low-dose, and high-dose groups with 40 patients in each group. The control group was treated with basic Western medicine. The low-dose and high-dose groups were treated with 0.7 g SXSHP once a day in the morning and twice a day in the morning and evening, respectively. The assessments were performed on days 14 and 28. The traditional Chinese medicine symptom score, average blood flow velocity of vertebral artery and basilar artery, blood viscosity, blood lipids, serum C-reactive protein level (CRP), blood routine test, and liver and kidney function were compared before and after treatment among the 3 groups. RESULTS: In the evaluation of the traditional Chinese medicine symptom score, both low-dose and high-dose SXSHP treatments showed higher efficacy than the control group (P = .013). The average blood flow velocity of vertebral artery and basilar artery in the 3 groups showed an upward trend from baseline (P < .05). The blood viscosity and levels of fibrinogen, hematocrit, and CRP in the 3 groups showed a downward trend from baseline level (P < .05). The levels of total cholesterol, triglycerides, low-density lipoprotein, and CRP in the low-dose group and high-dose group were lower than those in the control group on day 28 (P < .05). There were no significant differences in the routine blood test and liver and kidney function between the low-dose and high-dose groups compared with the baseline values (P > .05). CONCLUSION: SXSHP effectively improved PCI vertigo by inhibiting blood viscosity, regulating blood lipid levels, anti-inflammation, and improving cerebrovascular blood flow without affecting liver and kidney functions.

Attentional vigilance of food information in disordered eating behaviors.

Introduction: Disordered eating behaviors (DEBs) are very common among female college students, which seriously endanger their health and well-being. Therefore, the study of the mechanism of DEBs can provide effective evidence for early detection and intervention. Methods: In total of 54 female college students were recruited and assigned to DEB group (n = 29) and healthy control (HC) group (n = 25) according to their scores in the Eating Attitudes Test-26 (EAT-26). Then, the Exogenous Cueing Task (ECT) was used to evaluate their reaction time (RT) to the location of a target dot preceded by a food or neutral cue. Results: The study found that compared with HC group, DEB group showed more attentional engagement to food stimuli, indicating that attentional vigilance to food information could be considered as a specific attentional bias of DEBs. Discussion: Our findings not only provide evidence of the potential mechanism of DEBs from the perspective of attentional bias, but also can be considered as an effective and objective indicator for early screening of subclinical eating disorders (EDs).

A Novel Framework in Quantifying Oscillatory Coupling to Gait Disturbance in Parkinson's Disease.

Phase-amplitude coupling (PAC) based on the uniform phase empirical mode decomposition (UPEMD) is proposed to improve the accuracy of PAC assessment. The framework is applied to investigate the mechanism and improvement measure of gait disturbance for Parkinson's disease (PD). Hß modulation is suppressed at the time of contralateral heel strikes and rebounds when the contralateral foot rests on the ground and the ipsilateral foot is raised. Prominent PACs exist between δ and Lß/Hß activities. Auditory cue improves the gait; meanwhile, it enhances the Hß modulation, and suppresses the δ-Lß/Hß PACs, which may rebound toward the before-cue stage afterward. Our findings suggest the proposed UPEMD-PAC is a useful framework in quantifying PAC with pre-determined frequencies, whereas the δ-Lß/Hß PACs in the subthalamic nucleus serve as potential biomarkers for gait disturbance in PD. Clinical Relevance- This manifests the efficacy of auditory cues on gait disturbance. The proposed framework may be useful in diagnosing the severity of motor impairment.

Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson's Disease.

Gait disturbance in Parkinson's disease (PD) can be ameliorated by sound stimulation. Given that excessive ß synchronization in basal ganglia is linked to motor impairment in PD, whether the frequency nesting interactions are associated with the gait problem is far from clear. To this end, the masking phase-amplitude coupling (PAC) method was proposed to overcome the trade-off between intrinsic nonlinearity/non-stationarity and demand for predetermined frequencies, normally extracted by the filter. In this study, we analyzed LFPs recorded from 13 patients (one female) with PD during stepping with bilateral deep brain electrodes implanted in the subthalamic nucleus (STN). We found that not only high-frequency oscillation (100-300 Hz) was modulated by ß (13-30 Hz) but also ß and γ amplitude were modulated by their low-frequency components in δ/θ/α and δ/θ/α/ß bands. These PAC values were suppressed by sound stimulation, along with an improvement in gait. We also showed that gait-related high-ß (Hß) modulation in the STN was sensitive to auditory cues, and Hß gait-phase modulation increased with a metronome. Meanwhile, phase-locking values (PLVs) across all frequencies were significantly suppressed around contralateral heel strikes, manifesting the contralateral step as a critical gait phase in gait initiation for PD. Only the PLVs around contralateral steps were sensitive to auditory cues. Our results support masking PAC as an effective method in exploring frequency nesting interactions in LFPs and reveal the linkages between sound stimulation and couplings related to gait phases in the STN. These findings raise the possibility that nesting interactions in the STN work as feasible biomarkers in alleviating gait disorders.

Sediment washing by EDTA and its reclamation by sodium polyamidoamine-multi dithiocarbamate.

Sodium polyamidoamine-multi dithiocarbamate (PAMAM-DTC) is a kind of heavy metals capturing agent, containing functional groups of dithiocarbamate that could strongly chelate heavy metals. In this paper, it was applied to precipitate heavy metal ions from meal-EDTA and reclaim EDTA during sediment washing process. The extracting performance of fresh EDTA was studied as a function of EDTA concentration, liquid/sediment (L/S), pH, and extraction time. Then the EDTA effluents were treated with PAMAM-DTC, Na2S and sodium diethyldithiocarbamate (DDTC) to compare their effectiveness on capturing metals from metal-EDTA complexes. Four divalent heavy metals were investigated (Pb, Cd, Cu, Zn). PAMAM-DTC shows much better performance. Pb, Cd and Cu could almost be precipitated completely by PAMAM-DTC under the dosage of 350 mg L-1, while Zn could be only partly precipitated which may due to its failure in competition with the other three metal ions on chelation with PAMAM-DTC. The reclaimed EDTA was reused in three cycles of sediment washing, and the amount of heavy metals extracted just slightly decreased in each cycle.